Changes in Liver Volume in Patients with Chronic Hepatitis C Undergoing Antiviral Therapy.
J Clin Exp Hepatol
; 6(1): 15-20, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-27194891
ABSTRACT
AIM:
Liver volumetric analysis has not been used to detect hepatic remodelling during antiviral therapy before. We measured liver volume (LV) changes on volumetric magnetic resonance imaging during hepatitis C antiviral therapy.METHODS:
22 biopsy-staged patients (median [range] age 45(19-65) years; 9F, 13M) with chronic hepatitis C virus infection were studied. LV was measured at the beginning, end of treatment and 6 months post-treatment using 3D T1-weighted acquisition, normalised to patient weight. Liver outlines were drawn manually on 4 mm thick image slices and LV calculated. Inter-observer agreement was analysed. Patients were also assessed longitudinally using biochemical parameters and liver stiffness using Fibroscan™.RESULTS:
Sustained viral response (SVR) was achieved in 13 patients with a mean baseline LV/kg of 0.022 (SD 0.004) L/kg. At the end of treatment, the mean LV/kg was 0.025 (SD 0.004, P = 0.024 cf baseline LV/kg) and 0.026 (SD 0.004, P = 0.008 cf baseline LV/kg) 6 months post-treatment (P = 0.030 cf baseline, P = 0.004). Body weight-corrected end of treatment LV change was significantly higher in patients with SVR compared to patients not attaining SVR (P = 0.050). End of treatment LV change was correlated to initial ALT (R (2) = 0.479, P = 0.037), but not APRI, AST, viral load or liver stiffness measurements. There was a correlation of 0.89 between observers for measured slice thickness.CONCLUSIONS:
LV increased during anti-viral treatment, while the body weight-corrected LV increase persisted post-antiviral therapy and was larger in patients with SVR.
ALT, Alanine aminotransferase; APRI, Aspartate transaminase to platelet ratio index; AST, Aspartate transaminase; CHC, Chronic hepatitis C; CLD, Chronic liver disease; CT, Computed tomography; EASL, European Association for the Study of the Liver; HCC, Hepatocellular carcinoma; HCV, Hepatitis C virus; LV, Liver volume; MRI, Magnetic resonance imaging; NAFLD, Non-alcoholic fatty liver disease; NI, Necroinflammatory; SVR, Sustained viral response; hepatitis C virus; liver volume; magnetic resonance imaging; sustained viral response
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Clin Exp Hepatol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido