Retrospective hepatitis C seroprevalence screening in the antenatal setting-should we be screening antenatal women?
BMJ Open
; 6(5): e010661, 2016 05 26.
Article
en En
| MEDLINE
| ID: mdl-27231001
ABSTRACT
OBJECTIVES:
An unlinked anonymous seroprevalence study was conducted to estimate the prevalence of hepatitis C virus (HCV) infection in samples derived from antenatal clinic attendees at 2 East London Hospitals. An unexpectedly high HCV seroprevalence of 2.6% (1.2% viraemic) had been revealed during an unlinked study of the emergency department at 1 of these hospitals.DESIGN:
1000 stored residual samples were tested for HCV antibody (anti-HCV) and reactive samples were further tested for HCV RNA. The study was reviewed by the East Midland NRES ethics committee project ID 181154, approval number 15/WS/0125.RESULTS:
The anti-HCV reactivity rate was 0.5% (5/1000) with 0.1% (1/1000) confirmed viraemic. Prevalence for the other blood-borne viruses was higher 1% (10/1000) were hepatitis B surface antigen positive and 0.3% were HIV antigen/antibody positive (3/1000). There were no co-infections.CONCLUSIONS:
More data to establish the prevalence of HCV in the antenatal population is needed. The addition of anti-HCV testing to the well-established antenatal screening programme provides a unique opportunity to impact on the health of pregnant women, their children, partners and future pregnancies in this new era of treatment for hepatitis C.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
ARN Viral
/
Hepatitis C
/
Hepacivirus
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
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Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Middle aged
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Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
BMJ Open
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido