VBP15, a novel dissociative steroid compound, reduces NF&#954;B-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis.

Damsker, Jesse M; Conklin, Laurie S; Sadri, Soheil; Dillingham, Blythe C; Panchapakesan, Karuna; Heier, Christopher R; McCall, John M; Sandler, Anthony D

VBP15, a novel dissociative steroid compound, reduces NFκB-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis.

Damsker, Jesse M; Conklin, Laurie S; Sadri, Soheil; Dillingham, Blythe C; Panchapakesan, Karuna; Heier, Christopher R; McCall, John M; Sandler, Anthony D.

Afiliación

Damsker JM; ReveraGen BioPharma Inc., 155 Gibbs St. Suite 433, Rockville, MD, 20850, USA. Jesse.Damsker@reveragen.com.
Conklin LS; The Joseph E. Robert Center for Surgical Care, Children's National Health System, Washington, DC, 20010, USA.
Sadri S; The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, Washington, DC, 20010, USA.
Dillingham BC; The Joseph E. Robert Center for Surgical Care, Children's National Health System, Washington, DC, 20010, USA.
Panchapakesan K; The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, Washington, DC, 20010, USA.
Heier CR; Research Center for Genetic Medicine, Children's National Health System, Washington, DC, 20010, USA.
McCall JM; Research Center for Genetic Medicine, Children's National Health System, Washington, DC, 20010, USA.
Sandler AD; Research Center for Genetic Medicine, Children's National Health System, Washington, DC, 20010, USA.

Inflamm Res ; 65(9): 737-43, 2016 Sep.

Article en En | MEDLINE | ID: mdl-27261270

Asunto(s)

Antiinflamatorios/uso terapéutico; Colitis/tratamiento farmacológico; Pregnadienodioles/uso terapéutico; Animales; Antiinflamatorios/farmacología; Tamaño Corporal/efectos de los fármacos; Células Cultivadas; Colitis/inducido químicamente; Colitis/metabolismo; Citocinas/genética; Citocinas/metabolismo; Modelos Animales de Enfermedad; Células Epiteliales/efectos de los fármacos; Células Epiteliales/metabolismo; Femenino; Humanos; Masculino; Ratones Endogámicos BALB C; FN-kappa B/metabolismo; Pregnadienodioles/farmacología; Ácido Trinitrobencenosulfónico

Palabras clave

Autoimmunity; Glucocorticoids; Inflammation; Inflammatory bowel disease

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pregnadienodioles / Colitis / Antiinflamatorios Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Inflamm Res Asunto de la revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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