Engineering Biomolecular Switches for Dynamic Metabolic Control.
Adv Biochem Eng Biotechnol
; 162: 45-76, 2018.
Article
en En
| MEDLINE
| ID: mdl-27277392
ABSTRACT
Living organisms have been exploited as production hosts for a large variety of compounds. To improve the efficiency of bioproduction, metabolic pathways in an organism are usually manipulated by various genetic modifications. However, bottlenecks during the conversion of substrate to a desired product may result from cellular regulations at different levels. Dynamic regulation of metabolic pathways according to the need of cultivation process is therefore essential for developing effective bioprocesses, but represents a major challenge in metabolic engineering and synthetic biology. To this end, switchable biomolecules which can sense the intracellular concentrations of metabolites with different response types and dynamic ranges are of great interest. This chapter summarizes recent progress in the development of biomolecular switches and their applications for improvement of bioproduction via dynamic control of metabolic fluxes. Further studies of bioswitches and their applications in industrial strain development are also discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ingeniería Metabólica
/
Metabolismo
Idioma:
En
Revista:
Adv Biochem Eng Biotechnol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania