Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling.
Mol Med Rep
; 14(2): 1365-70, 2016 Aug.
Article
en En
| MEDLINE
| ID: mdl-27278131
ABSTRACT
Puerarin is an important active ingredient in the root of kudzu vine due to its pharmacological properties. The aim of the present study is to contribute to the existing knowledge of the effect of puerarin in the attenuation of inflammation and oxidation in mice with collagen antibody-induced arthritis via tolllike receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling. Arthritis was induced using injection of antitype II collagen antibodies. Treatment with puerarin was observed to significantly decrease clinical scoring of the collagen antibodyinduced arthritis and suppress oxidative stress and the inflammatory response in mice. Furthermore, puerarin was demonstrated to inhibit mRNA expression of matrix metalloproteinase9 and protein expression of TLR4 following collagen antibody-induced arthritis in mice. The effect of puerarin may be associated with the suppression of NFκB activity in collagen antibodyinduced arthritis mice. Furthermore, upregulation of phosphorylated (p)Janus kinase 2 and psignal transducer and activator of transcription 3 protein expression was suppressed by puerarin. The results of the present study indicate, for the first time, the effect of puerarin to attenuate inflammation and oxidation in mice with collagen antibodyinduced arthritis via TLR4/NF-κB signaling.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxidación-Reducción
/
Artritis Experimental
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Transducción de Señal
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FN-kappa B
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Receptor Toll-Like 4
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Isoflavonas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Mol Med Rep
Año:
2016
Tipo del documento:
Article