Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma.
Mol Cell Oncol
; 3(2): e1095271, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-27308626
ABSTRACT
Adeno-associated virus type 2 (AAV2) is a defective DNA virus that was previously considered to be non-pathogenic. We identified somatic AAV2 integration in a subset of 11 hepatocellular carcinomas (HCC) that mainly developed in normal liver without known etiology through recurrent insertional mutagenesis in cancer driver genes such as telomerase reverse transcriptase (TERT), cyclin A2 (CCNA2), cyclin E1 (CCNE1), tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10), and lysine (K)-specific methyltransferase 2B (KMT2B).
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Mol Cell Oncol
Año:
2016
Tipo del documento:
Article