GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain.
ACS Med Chem Lett
; 7(6): 552-7, 2016 Jun 09.
Article
en En
| MEDLINE
| ID: mdl-27326325
ABSTRACT
The BRPF (Bromodomain and PHD Finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. A selective benzimidazolone BRPF1 inhibitor showing micromolar activity in a cellular target engagement assay was recently described. Herein, we report the optimization of this series leading to the identification of a superior BRPF1 inhibitor suitable for in vivo studies.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
ACS Med Chem Lett
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido