[EFFECT OF SHORT-TERM DRY IMMERSION ON PROTEOLYTIC SIGNALING IN HUMAN SOLEUS MUSCLE].
Aviakosm Ekolog Med
; 50(1): 28-34, 2016.
Article
en Ru
| MEDLINE
| ID: mdl-27344854
ABSTRACT
The signaling processes initiating proteolytic events in m. soleus of humans during short-term exposure in the non-weight bearing conditions were analyzed. Dry immersion (DI) was used to induce weight deprivation over 3 days. Western blotting was used to define the IRS-1 content, total and phosphorylated neuronal NO-synthase (nNOS), AMP-activated protein kinase (AMPK) that control the anabolic and catabolic pathways, and concentrations of cytoskeletal protein desmin and Ca²âº-activated protease calpin. Already on day-3 of DI calpain-dependent proteolysis manifests itself by reductions in both the total content and level of nNOS phosphorilation. Moreover, AMPK phosphorilation was decreased drastically.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Músculo Esquelético
/
Óxido Nítrico Sintasa de Tipo I
/
Proteínas Quinasas Activadas por AMP
/
Proteolisis
Límite:
Humans
Idioma:
Ru
Revista:
Aviakosm Ekolog Med
Asunto de la revista:
MEDICINA AEROESPACIAL
/
SAUDE AMBIENTAL
Año:
2016
Tipo del documento:
Article