Immunogenomics of gastrointestinal nematode infection in ruminants - breeding for resistance to produce food sustainably and safely.
Parasite Immunol
; 38(9): 569-86, 2016 Sep.
Article
en En
| MEDLINE
| ID: mdl-27387842
ABSTRACT
Gastrointestinal nematode (GIN) infection of ruminants represents a major health and welfare challenge for livestock producers worldwide. The emergence of anthelmintic resistance in important GIN species and the associated animal welfare concerns have stimulated interest in the development of alternative and more sustainable strategies aimed at the effective management of the impact of GINs. These integrative strategies include selective breeding using genetic/genomic tools, grazing management, biological control, nutritional supplementation, vaccination and targeted selective treatment. In this review, the logic of selecting for "resistance" to GIN infection as opposed to "resilience" or "tolerance" is discussed. This is followed by a review of the potential application of immunogenomics to genetic selection for animals that have the capacity to withstand the impact of GIN infection. Advances in relevant genomic technologies are highlighted together with how these tools can be advanced to support the integration of immunogenomic information into ruminant breeding programmes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Rumiantes
/
Cruzamiento
/
Resistencia a la Enfermedad
/
Parasitosis Intestinales
/
Infecciones por Nematodos
Límite:
Animals
Idioma:
En
Revista:
Parasite Immunol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Irlanda