Micron-sized and submicron-sized aerosol deposition in a new ex vivo preclinical model.
Respir Res
; 17(1): 78, 2016 07 07.
Article
en En
| MEDLINE
| ID: mdl-27388488
ABSTRACT
BACKGROUND:
The knowledge of where particles deposit in the respiratory tract is crucial for understanding the health effects associated with inhaled drug particles.METHOD:
An ex vivo study was conducted to assess regional deposition patterns (thoracic vs. extrathoracic) of radioactive polydisperse aerosols with different size ranges [0.15 µm-0.5 µm], [0.25 µm-1 µm] and [1 µm-9 µm]. SPECT/CT analyses were performed complementary in order to assess more precisely the regional deposition of aerosols within the pulmonary tract. Experiments were set using an original respiratory tract model composed of a human plastinated head connected to an ex vivo porcine pulmonary tract. The model was ventilated by passive expansion, simulating pleural depressions. Aerosol was administered during nasal breathing.RESULTS:
Planar scintigraphies allowed to calculate the deposited aerosol fractions for particles in the three size ranges from sub-micron to micron The deposited fractions obtained, for thoracic vs. extra-thoracic regions respectively, were 89 ± 4 % vs. 11 ± 4 % for [0.15 µm-0.5 µm], 78 ± 5 % vs. 22 ± 5 % for [0.25 µm-1 µm] and 35 ± 11 % vs.65 ± 11 % for [1 µm-9 µm].CONCLUSION:
Results obtained with this new ex vivo respiratory tract model are in good agreement with the in vivo data obtained in studies with baboons and humans.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sistema Respiratorio
/
Pentetato de Tecnecio Tc 99m
/
Radiofármacos
/
Cabeza
/
Modelos Anatómicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Respir Res
Año:
2016
Tipo del documento:
Article
País de afiliación:
Francia