Long-term survival of patients with mismatch repair protein-deficient, high-stage ovarian clear cell carcinoma.
Histopathology
; 70(2): 309-313, 2017 Jan.
Article
en En
| MEDLINE
| ID: mdl-27442838
ABSTRACT
AIMS:
Gynaecological cancer patients with germline mutations appear to have a better prognosis than those with sporadic malignancies. Following the observation of long-term survival in a patient with stage III ovarian clear cell carcinoma (CCC) and possible Lynch syndrome (LS), DNA mismatch repair (MMR) protein immunohistochemistry was performed in a series of high-stage CCC and correlated with patient outcomes. METHODS ANDRESULTS:
Thirty-two consecutive cases of stage III/IV ovarian CCCs accessioned between 1992 and 2015 were examined. The tumours from two patients (6%), including the index case, showed loss of MSH2/MSH6 expression while MLH1/PMS2 staining was retained. The index patient subsequently developed colonic and rectal carcinomas that were also MSH2/MSH6-deficient, while the second patient had a genetically confirmed germline MSH2 mutation. All other tumours showed retained expression of the four MMR proteins. The two patients with MMR protein-deficient tumours were alive 160 months and 124 months following surgery, whereas the median survival of patients with MMR protein-intact CCCs was 11.8 months (75th and 25th percentiles of 8.1 months and 39.3 months, respectively), with 21 patients deceased due to tumour.CONCLUSIONS:
Larger studies are required but high-stage, MMR protein-deficient CCCs may have a relatively favourable prognosis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
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Neoplasias Colorrectales Hereditarias sin Poliposis
/
Adenocarcinoma de Células Claras
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Histopathology
Año:
2017
Tipo del documento:
Article
País de afiliación:
Australia