Your browser doesn't support javascript.
loading
Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout.
Das Gupta, Esha; Sakthiswary, Rajalingham; Lee, Shing L; Wong, Shew F; Hussein, Heselynn; Gun, Suk C.
Afiliación
  • Das Gupta E; Department of Medicine, International Medical University, Seremban, Malaysia.
  • Sakthiswary R; Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
  • Lee SL; Department of Medicine, International Medical University, Seremban, Malaysia.
  • Wong SF; Department of Medicine, International Medical University, Seremban, Malaysia.
  • Hussein H; Department of Medicine, Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia.
  • Gun SC; Department of Medicine, Tuanku Jaafar Hospital, Seremban, Malaysia.
Int J Rheum Dis ; 21(3): 705-709, 2018 Mar.
Article en En | MEDLINE | ID: mdl-27456670
ABSTRACT

AIM:

The main objective of this study is to elucidate the clinical significance of the SLC2A9/GLUT9 rs11722228 polymorphism among male gout patients.

METHOD:

We consecutively recruited all newly diagnosed male gout patients who were treatment-naive from the rheumatology outpatient clinics of two Malaysian hospitals. Age-matched healthy male adults were employed as controls. All subjects were tested for the SLC2A9/GLUT9 rs11722228 genotypes, serum uric acid (SUA), urine uric acid and creatinine levels. All gout subjects were examined for the presence of tophi and sonographically screened for renal calculi.

RESULTS:

A total of 73 male gout patients and 73 age-matched healthy male adults were recruited in this study. The genotypic frequencies of SLC2A9/GLUT9 rs1172228 did not differ significantly between the gout cases and the healthy controls. The gout subjects with the CC genotype had significantly higher SUA levels (P = 0.002), family history of gout (P < 0.050) and the occurrence of renal calculi (P = 0.026). The SUA-adjusted odds ratios (OR) of the occurrence of renal calculi in the CC genotype (OR = 1 [reference]) was significantly higher than the CT genotype (OR = 0.338, 95%CI 0.141-0.813) and the TT genotype (OR = 0.271, 95%CI 0.086-0.854).

CONCLUSIONS:

The genotypic distribution of SLC2A9/GLUT9 rs1172228 in male gout patients did not differ significantly from that of healthy male controls. However, the CC genotype in gout had significant associations with higher levels of SUA, renal calculi and a positive family history of gout.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cálculos Renales / Polimorfismo de Nucleótido Simple / Proteínas Facilitadoras del Transporte de la Glucosa / Gota Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: Asia Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Malasia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cálculos Renales / Polimorfismo de Nucleótido Simple / Proteínas Facilitadoras del Transporte de la Glucosa / Gota Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: Asia Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Malasia