Ceanothane-type triterpenoids from Cyphostemma adenocaule.
Arch Pharm Res
; 2016 Jul 26.
Article
en En
| MEDLINE
| ID: mdl-27461028
ABSTRACT
Phytochemical investigation of the methanol extract of Cyphostemma adenocaule liana (bark and wood) led to the isolation of two new ceanothane-type triterpenoids, cyphostemmic acid A 1 and cyphostemmic acid B 2, together with the known triterpenoids 3-7, ß-sitosterol and its glucoside. The structures of the isolated compounds were established by 1D- and 2D-NMR spectroscopy. Ozonolysis of cyphostemmic acid A 1, epigouanic acid A 3 and betulin 6 yielded semisynthetic derivatives, cyphostemmic acid C 8, cyphostemmic acid D 9, and 3ß,28-dihydroxy-30-norlupan-20-one 10 respectively. Compounds 1-4, 6, 8-10 were tested in vitro, for their antiplasmodial activity against Plasmodium falciparum 3D7 strain and showed weak activity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Arch Pharm Res
Año:
2016
Tipo del documento:
Article
País de afiliación:
Camerún