Synthesis and immunostimulatory activity of substituted TLR7 agonists.
Bioorg Med Chem Lett
; 26(17): 4246-9, 2016 09 01.
Article
en En
| MEDLINE
| ID: mdl-27476423
ABSTRACT
Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adenina
/
Adyuvantes Inmunológicos
/
Receptor Toll-Like 7
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos