The efficacy of single premedication with antihistamines for radiocontrast media hypersensitivity.
Asia Pac Allergy
; 6(3): 164-7, 2016 Jul.
Article
en En
| MEDLINE
| ID: mdl-27489788
ABSTRACT
BACKGROUND:
Single premedication with antihistamines for radiocontrast media (RCM) hypersensitivity is frequently used in real world at the emergent situation although its efficacy is not proven.OBJECTIVE:
To evaluate the effect of intravenous antihistamines as a premedication in general population who had experience of mild adverse reactions to iodinated RCM.METHODS:
A retrospective observational study on 14,785 subjects who had RCM-enhanced computed tomography scans between January 2014 and December 2015 in Seoul National University Hospital Gangnam Healthcare Center, Seoul, South Korea.RESULTS:
Among 453 subjects who had a history of mild RCM-induced hypersensitivity reactions, 273 subjects had a single premedication of intravenous antihistamine. When comparing antihistamine-premedication group and nonpremedication group, there is no protective effect of antihistamines on the incidence rate and severity of hypersensitivity (10.6% vs. 11.7%, p = 0.729).CONCLUSION:
The clinical efficacy of a single premedication of antihistamines for mild RCM-induced hypersensitivity was not confirmed.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Asia Pac Allergy
Año:
2016
Tipo del documento:
Article