Mutagenic induction of an ultra-fast water-chain proton wire.

Wineman-Fisher, Vered; Simkovich, Ron; Huppert, Dan; Trujillo, Kristina; Remington, S James; Miller, Yifat

Wineman-Fisher, Vered; Simkovich, Ron; Huppert, Dan; Trujillo, Kristina; Remington, S James; Miller, Yifat.

Afiliación

Wineman-Fisher V; Department of Chemistry, Ben-Gurion University of the Negev, P.O. Box 653, Be'er Sheva 84105, Israel. ymiller@bgu.ac.il and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beér-Sheva 84105, Israel.
Simkovich R; Raymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University, Tel Aviv 69978, Israel.
Huppert D; Raymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University, Tel Aviv 69978, Israel.
Trujillo K; Department of Physics and Institute of Molecular Biology, University of Oregon, Eugene, USA.
Remington SJ; Department of Physics and Institute of Molecular Biology, University of Oregon, Eugene, USA.
Miller Y; Department of Chemistry, Ben-Gurion University of the Negev, P.O. Box 653, Be'er Sheva 84105, Israel. ymiller@bgu.ac.il and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beér-Sheva 84105, Israel.

Phys Chem Chem Phys ; 18(33): 23089-95, 2016 Aug 17.

Article en En | MEDLINE | ID: mdl-27492977

ABSTRACT

ABSTRACT

Replacement of the hydroxyl group of a hydrophilic sidechain by an H atom in the proton wire of GFP induces formation of a water-chain proton wire. Surprisingly, this "non-native" water chain functions as a proton wire with response times within 10 ps of the wild type protein. This remarkable rate retention is understood as a natural consequence of the well-known Grotthuss mechanism of proton transfer in water.

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Phys Chem Chem Phys Asunto de la revista: BIOFISICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Israel

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google