Look Out Autophagy, Ubiquilin UPS Its Game.
Cell
; 166(4): 797-799, 2016 Aug 11.
Article
en En
| MEDLINE
| ID: mdl-27518558
ABSTRACT
Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has remained unknown. Hjerpe et. al now report that Ubiquilin-2 enables the ubiquitin proteasome system (UPS) to single-handedly clear aggregated proteins, a cellular function previously thought to rely at least partially on autophagy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ubiquitina
/
Complejo de la Endopetidasa Proteasomal
Límite:
Humans
Idioma:
En
Revista:
Cell
Año:
2016
Tipo del documento:
Article
País de afiliación:
Israel