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Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine ß-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.
Druzhyna, Nadiya; Szczesny, Bartosz; Olah, Gabor; Módis, Katalin; Asimakopoulou, Antonia; Pavlidou, Athanasia; Szoleczky, Petra; Gerö, Domokos; Yanagi, Kazunori; Törö, Gabor; López-García, Isabel; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Zatarain, John R; Chao, Celia; Papapetropoulos, Andreas; Hellmich, Mark R; Szabo, Csaba.
Afiliación
  • Druzhyna N; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Szczesny B; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Olah G; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Módis K; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA; Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA.
  • Asimakopoulou A; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Greece; Center of Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation of the Academy of Athens, Greece.
  • Pavlidou A; National and Kapodistrian University of Athens, School of Pharmacy, Athens, Greece.
  • Szoleczky P; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Gerö D; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Yanagi K; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Törö G; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • López-García I; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Myrianthopoulos V; National and Kapodistrian University of Athens, School of Pharmacy, Athens, Greece.
  • Mikros E; National and Kapodistrian University of Athens, School of Pharmacy, Athens, Greece.
  • Zatarain JR; Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA.
  • Chao C; Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA.
  • Papapetropoulos A; Center of Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation of the Academy of Athens, Greece; National and Kapodistrian University of Athens, School of Pharmacy, Athens, Greece.
  • Hellmich MR; Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA; CBS Therapeutics Inc., Galveston, TX, USA.
  • Szabo C; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA; CBS Therapeutics Inc., Galveston, TX, USA. Electronic address: szabocsaba@aol.com.
Pharmacol Res ; 113(Pt A): 18-37, 2016 11.
Article en En | MEDLINE | ID: mdl-27521834
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benserazida / Neoplasias del Colon / Cistationina betasintasa Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benserazida / Neoplasias del Colon / Cistationina betasintasa Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos