MiR-22 promotes porcine reproductive and respiratory syndrome virus replication by targeting the host factor HO-1.
Vet Microbiol
; 192: 226-230, 2016 Aug 30.
Article
en En
| MEDLINE
| ID: mdl-27527787
ABSTRACT
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viruses affecting the swine industry worldwide. MicroRNAs (miRNAs) play vital roles in virus-host interactions by regulating the expression of viral or host gene at posttranscriptional level. Our previous research showed that PRRSV infection down-regulates the expression of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, and overexpression of HO-1 inhibits PRRSV replication. In this study, we demonstrate that host miRNA miR-22 can downregulate HO-1 expression by directly targeting its 3' untranslated region. Suppression of HO-1 expression by miR-22 facilitates PRRSV replication. This work suggests that PRRSV may utilize cellular miRNA to modify antiviral host factor expression, enabling viral replication, which not only provides new insights into virus-host interactions during PRRSV infection, but also suggests potential therapies for PRRSV infection.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Replicación Viral
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Regulación Enzimológica de la Expresión Génica
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Virus del Síndrome Respiratorio y Reproductivo Porcino
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MicroARNs
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Hemo-Oxigenasa 1
Límite:
Animals
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Humans
Idioma:
En
Revista:
Vet Microbiol
Año:
2016
Tipo del documento:
Article