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Revised Estimates for the Number of Human and Bacteria Cells in the Body.
Sender, Ron; Fuchs, Shai; Milo, Ron.
Afiliación
  • Sender R; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
  • Fuchs S; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
  • Milo R; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
PLoS Biol ; 14(8): e1002533, 2016 08.
Article en En | MEDLINE | ID: mdl-27541692
Reported values in the literature on the number of cells in the body differ by orders of magnitude and are very seldom supported by any measurements or calculations. Here, we integrate the most up-to-date information on the number of human and bacterial cells in the body. We estimate the total number of bacteria in the 70 kg "reference man" to be 3.8·1013. For human cells, we identify the dominant role of the hematopoietic lineage to the total count (≈90%) and revise past estimates to 3.0·1013 human cells. Our analysis also updates the widely-cited 10:1 ratio, showing that the number of bacteria in the body is actually of the same order as the number of human cells, and their total mass is about 0.2 kg.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bacterias / Recuento de Células / Carga Bacteriana / Microbiota Límite: Adult / Humans / Male Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Israel

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bacterias / Recuento de Células / Carga Bacteriana / Microbiota Límite: Adult / Humans / Male Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Israel