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Intramedullary Spinal Cord Germinoma: A Case Report and Review of Literature.
Nikitovic, Marina; Grujicic, Danica; Skender Gazibara, Milica; Stanic, Dragana; Bokun, Jelena; Saric, Milan.
Afiliación
  • Nikitovic M; Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Institute for Oncology and Radiology of Serbia, Clinic for Radiation Oncology, Belgrade, Serbia. Electronic address: marina.nikitovic@ncrc.ac.rs.
  • Grujicic D; Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic of Neurosurgery, Clinical Centre of Serbia, Belgrade, Serbia.
  • Skender Gazibara M; Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Stanic D; Institute for Oncology and Radiology of Serbia, Clinic for Radiation Oncology, Belgrade, Serbia.
  • Bokun J; Institute for Oncology and Radiology of Serbia, Clinic for Radiation Oncology, Belgrade, Serbia.
  • Saric M; Institute for Oncology and Radiology of Serbia, Clinic for Radiation Oncology, Belgrade, Serbia.
World Neurosurg ; 95: 392-398, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27554307
ABSTRACT
Primary spinal cord germinomas are an extremely rare group of tumors, most commonly reported as single cases in young Japanese adults. They usually present as intramedullary lesions located in the thoracic and thoracolumbar spine. The importance of preoperative diagnosis lies in the fact that by using radiotherapy and chemotherapy, even without surgery, a good cure rate can be achieved in patients with spinal cord germinoma. These tumors, however, demonstrate unspecific imaging characteristics, and only some secrete tumor markers. Therefore, a diagnosis of these lesions before biopsy or resection with pathohistologic examination can be difficult. We present a case of a 28-year-old white man with intramedullary spinal cord germinoma. The tumor was resected completely with electrophysiological monitoring, without a biopsy and frozen section analysis. Postoperative radiotherapy also was part of the treatment. The patient has had no relapse 4.5 years after diagnosis; however, significant neurologic deficits remain. Although not as frequent in white patients, germinoma should be considered as differential diagnosis in cases of young adult patients with intramedullary tumor in the thoracic or thoracolumbar spine. Therefore, spinal mass surgery should commence with a biopsy and intraoperative frozen section analysis. In this way, attempting a gross total resection becomes unnecessary. With an approach of intraoperative biopsy and frozen section analysis, a considerable amount of postoperative neurologic deficits can be reduced.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compresión de la Médula Espinal / Neoplasias de la Médula Espinal / Germinoma Tipo de estudio: Etiology_studies Límite: Adult / Humans / Male Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2016 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compresión de la Médula Espinal / Neoplasias de la Médula Espinal / Germinoma Tipo de estudio: Etiology_studies Límite: Adult / Humans / Male Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2016 Tipo del documento: Article