Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.
J Pediatr Gastroenterol Nutr
; 64(2): 180-185, 2017 02.
Article
en En
| MEDLINE
| ID: mdl-27632431
ABSTRACT
The development of sustainable intestinal organoid cell culture has emerged as a new modality for the study of intestinal function and cellular processes. Organoid culture is providing a new testbed for therapeutic research and development. Intestinal organoids, self-renewing 3-dimensional structures comprised intestinal stem cells and their differentiated epithelial progeny allow for more facile and robust exploration of cellular activity, cell organization and structure, genetic manipulation, and vastly more physiologic modeling of intestinal response to stimuli as compared to traditional 2-dimensional cell line cultures. Intestinal organoids are affecting a wide variety of research into gastrointestinal pathology. The purpose of this review is to discuss the current state-of-the-art and future effect of research using enteroids and colonoids (organoids grown from the small and large intestines, respectively).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Organoides
/
Investigación Biomédica
/
Enfermedades Intestinales
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2017
Tipo del documento:
Article
País de afiliación:
Canadá