[HER-2 expression and clinical significance in esophagogastric junction adenocarcinoma (Siewert type â
¡)].
Zhonghua Zhong Liu Za Zhi
; 38(9): 667-71, 2016 Sep 23.
Article
en Zh
| MEDLINE
| ID: mdl-27647398
ABSTRACT
OBJECTIVE:
To investigate the human epidermal growth factor receptor-2 (HER-2) expression in esophagogastirc junction adenocarcinoma(Siewert type â ¡)and its clinical significance.METHODS:
A total of 180 patients with esophagogastric junction adenocarcinoma (Siewert type â ¡) were included in this study. The HER-2 expression was detected by immunohistochemistry (IHC), and fluorescence in situ hybridization (FISH) analysis was performed to assess the HER-2 gene amplification in the IHC-positive and IHC-weak positive cases.RESULTS:
HER-2 overexpression (3+ ), weak positive (2+ ) and negative (1+ /0) was 11.7%(21/180), 8.9%(16/180), and 79.4%(143/180), respectively. The FISH analysis showed HER-2 gene amplification in 95.2%(20/21) of HER-2(3+ ) cases and 18.8% (3/16) of HER-2(2+ ) cases. The concordance rate between IHC and FISH was 95.2%. Overexpression of HER-2(3+ ) was associated with the tumor differentiation (P<0.05), and irrelevant to age, sex, pT stage, pN stage, pM stage and pTNM stage (P>0.05). The median overall survival time (OS) was 13 months in HER-2(3+ ) patients, significantly shorter than the 21 months in HER-2(2+ ) and HER-2(+ /-) cases (P<0.01).CONCLUSIONS:
Approximately 11.7% of the patients with esophagogastric junction adenocarcinoma (Siewert type â ¡) are HER-2-positive on IHC. HER-2 overexpression is associated with the tumor differentiation. IHC can be used as a screening test for the positive expression of HER-2 in the esophagogastirc junction adenocarcinoma (Siewert type â ¡). However, FISH detection can be used as a more reliable detection method.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Neoplasias Esofágicas
/
Adenocarcinoma
/
Unión Esofagogástrica
Límite:
Humans
Idioma:
Zh
Revista:
Zhonghua Zhong Liu Za Zhi
Año:
2016
Tipo del documento:
Article
País de afiliación:
China