3-Hz subthreshold oscillations of CA2 neurons In vivo.
Hippocampus
; 26(12): 1570-1578, 2016 12.
Article
en En
| MEDLINE
| ID: mdl-27650674
ABSTRACT
The CA2 region is unique in the hippocampus; it receives direct synaptic innervations from several hypothalamic nuclei and expresses various receptors of neuromodulators, including adenosine, vasopressin, and oxytocin. Furthermore, the CA2 region may have distinct brain functions, such as the control of instinctive and social behaviors; however, little is known about the dynamics of the subthreshold membrane potentials of CA2 neurons in vivo. We conducted whole-cell current-clamp recordings from CA2 pyramidal cells in urethane-anesthetized mice and monitored the intrinsic fluctuations in their membrane potentials. The CA2 pyramidal cells emitted spontaneous action potentials at mean firing rates of â¼0.8 Hz. In approximately half of the neurons, the subthreshold membrane potential oscillated at â¼3 Hz. In two neurons, we obtained simultaneous recordings of local field potentials from the CA1 stratum radiatum and demonstrated that the 3-Hz oscillations of CA2 neurons were not correlated with CA1 field potentials. In tetrodotoxin-perfused acute hippocampal slices, the membrane potentials of CA2 pyramidal cells were not preferentially entrained to 3-Hz sinusoidal current inputs, which suggest that intracellular 3-Hz oscillations reflect the neuronal dynamics of the surrounding networks. © 2016 Wiley Periodicals, Inc.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Piramidales
/
Región CA2 Hipocampal
/
Potenciales de la Membrana
Límite:
Animals
Idioma:
En
Revista:
Hippocampus
Asunto de la revista:
CEREBRO
Año:
2016
Tipo del documento:
Article
País de afiliación:
Japón