Cognitive Impairment Is Associated with a Low Omega-3 Index in the Elderly: Results from the KORA-Age Study.
Dement Geriatr Cogn Disord
; 42(3-4): 236-245, 2016.
Article
en En
| MEDLINE
| ID: mdl-27701160
ABSTRACT
BACKGROUND:
Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults.METHODS:
Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoic acid (omega-3 index) were measured in erythrocytes as a percentage of total fatty acids. The categories low (<5.7), intermediate (5.7-6.8), and high (>6.8) levels of the omega-3 index were built using tertiles. The association between cognitive status and omega-3 levels was assessed by logistic regression analyses with adjustments for important concurrent risk factors of cognitive decline.RESULTS:
In the sex- and age-adjusted model (model 1), subjects with a low omega-3 index were at a significantly higher risk for cognitive impairment (OR 1.77, 95% CI 1.15-2.73, p = 0.009). This association remained stable after further adjusting for educational level (model 2; OR 1.75, 95% CI 1.13-2.71, p = 0.01) and metabolic risk factors (model 3; OR 1.77, 95% CI 1.14-2.75, p = 0.01). After further controlling for affective disorders (model 4), the association did not attenuate (OR 1.77, 95% CI 1.14-2.76, p = 0.01).CONCLUSION:
A robust association was found between low omega-3 levels and cognitive impairment in an elderly population. Further research is needed to understand the link between omega-3 PUFA and cognitive functioning.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácido Eicosapentaenoico
/
Ácidos Docosahexaenoicos
/
Eritrocitos
/
Disfunción Cognitiva
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Dement Geriatr Cogn Disord
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
/
PSIQUIATRIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Alemania