Early-Onset 5-Fluorouracil Toxicity in a Patient Negative for Dihydropyrimidine Dehydrogenase Mutations: The Clinical Course of Reversal with Uridine Triacetate.

Vaudo, Christine E; Gil, Brigitte; Galuski, Kari; Zarwan, Corrine; Nugent, Francis W

Vaudo, Christine E; Gil, Brigitte; Galuski, Kari; Zarwan, Corrine; Nugent, Francis W.

Afiliación

Vaudo CE; Department of Pharmacy, Lahey Hospital & Medical Center, Burlington, Massachusetts.
Gil B; Department of Pharmacy, Lahey Hospital & Medical Center, Burlington, Massachusetts.
Galuski K; Department of Hematology/Oncology, Lahey Hospital & Medical Center, Burlington, Massachusetts.
Zarwan C; Department of Hematology/Oncology, Lahey Hospital & Medical Center, Burlington, Massachusetts.
Nugent FW; Department of Hematology/Oncology, Lahey Hospital & Medical Center, Burlington, Massachusetts.

Pharmacotherapy ; 36(11): e178-e182, 2016 11.

Article en En | MEDLINE | ID: mdl-27716991

Asunto(s)

Acetatos/uso terapéutico; Antimetabolitos Antineoplásicos/efectos adversos; Neoplasias del Ano/tratamiento farmacológico; Fluorouracilo/efectos adversos; Uridina/análogos & derivados; Anciano; Antídotos/uso terapéutico; Antimetabolitos Antineoplásicos/administración & dosificación; Neoplasias del Ano/genética; Dihidrouracilo Deshidrogenasa (NADP)/genética; Fatiga/inducido químicamente; Fluorouracilo/administración & dosificación; Estudios de Seguimiento; Humanos; Masculino; Mucositis/inducido químicamente; Mucositis/tratamiento farmacológico; Mutación; Neutrófilos/metabolismo; Factores de Tiempo; Uridina/uso terapéutico

Palabras clave

5-fluorouracil; adverse drug reaction; early-onset toxicity; uridine triacetate

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias del Ano / Uridina / Fluorouracilo / Acetatos / Antimetabolitos Antineoplásicos Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: Pharmacotherapy Año: 2016 Tipo del documento: Article

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