Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
J Cell Physiol
; 232(9): 2550-2557, 2017 Sep.
Article
en En
| MEDLINE
| ID: mdl-27731506
ABSTRACT
Phosphatidylinositol (PI) signaling is an essential regulator of cell motility and proliferation. A portion of PI metabolism and signaling takes place in the nuclear compartment of eukaryotic cells, where an array of kinases and phosphatases localize and modulate PI. Among these, Diacylglycerol Kinases (DGKs) are a class of phosphotransferases that phosphorylate diacylglycerol and induce the synthesis of phosphatidic acid. Nuclear DGKalpha modulates cell cycle progression, and its activity or expression can lead to changes in the phosphorylated status of the Retinoblastoma protein, thus, impairing G1/S transition and, subsequently, inducing cell cycle arrest, which is often uncoupled with apoptosis or autophagy induction. Here we report for the first time not only that the DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, but also that its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression. J. Cell. Physiol. 232 2550-2557, 2017. © 2016 Wiley Periodicals, Inc.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Leucemia Eritroblástica Aguda
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Núcleo Celular
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Diacilglicerol Quinasa
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Proliferación Celular
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Puntos de Control de la Fase G1 del Ciclo Celular
Límite:
Humans
Idioma:
En
Revista:
J Cell Physiol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia