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Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome.
Hamlett, Eric D; Goetzl, Edward J; Ledreux, Aurélie; Vasilevko, Vitaly; Boger, Heather A; LaRosa, Angela; Clark, David; Carroll, Steven L; Carmona-Iragui, María; Fortea, Juan; Mufson, Elliott J; Sabbagh, Marwan; Mohammed, Abdul H; Hartley, Dean; Doran, Eric; Lott, Ira T; Granholm, Ann-Charlotte.
Afiliación
  • Hamlett ED; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
  • Goetzl EJ; Geriatric Research Center of the Jewish Home of San Francisco, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA.
  • Ledreux A; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
  • Vasilevko V; University of California, Irvine Institute for Memory Impairment and Neurological Disorders, Irvine, CA, USA.
  • Boger HA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Center on Aging, Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
  • LaRosa A; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
  • Clark D; Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
  • Carroll SL; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Carmona-Iragui M; Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau, Barcelona, Spain; Down Medical Center, Fundacío Catalana Síndrome de Down, Barcelona, Spain.
  • Fortea J; Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau, Barcelona, Spain; Down Medical Center, Fundacío Catalana Síndrome de Down, Barcelona, Spain.
  • Mufson EJ; Barrow Neurological Institute, Department of Neurobiology, Phoenix, AZ, USA.
  • Sabbagh M; Barrow Neurological Institute, Department of Neurobiology, Phoenix, AZ, USA.
  • Mohammed AH; Department of Psychology, Linnaeus University, Växjo, Sweden; Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.
  • Hartley D; Alzheimer's Association, Chicago, IL, USA.
  • Doran E; Department of Pediatrics, School of Medicine, University of California, Irvine, Orange, CA, USA.
  • Lott IT; Department of Pediatrics, School of Medicine, University of California, Irvine, Orange, CA, USA.
  • Granholm AC; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA; The Center on Aging, Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Center for Alzheimer Rese
Alzheimers Dement ; 13(5): 541-549, 2017 May.
Article en En | MEDLINE | ID: mdl-27755974
INTRODUCTION: Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD neuropathology would be valuable, as non-AD intellectual disabilities of DS and AD dementia overlap clinically. We hypothesized that elevations of amyloid ß (Aß) peptides and phosphorylated-tau in neuronal exosomes may document preclinical AD. METHODS: AD neuropathogenic proteins Aß1-42, P-T181-tau, and P-S396-tau were quantified by enzyme-linked immunosorbent assays in extracts of neuronal exosomes purified from blood of individuals with DS and age-matched controls. RESULTS: Neuronal exosome levels of Aß1-42, P-T181-tau, and P-S396-tau were significantly elevated in individuals with DS compared with age-matched controls at all ages beginning in childhood. No significant gender differences were observed. DISCUSSION: These early increases in Aß1-42, P-T181-tau, and P-S396-tau in individuals with DS may provide a basis for early intervention as targeted treatments become available.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome de Down / Exosomas / Enfermedad de Alzheimer Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome de Down / Exosomas / Enfermedad de Alzheimer Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos