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COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes.
Naaijen, Jilly; de Ruiter, Saskia; Zwiers, Marcel P; Glennon, Jeffrey C; Durston, Sarah; Lythgoe, David J; Williams, Steven C R; Banaschewski, Tobias; Brandeis, Daniel; Franke, Barbara; Buitelaar, Jan K.
Afiliación
  • Naaijen J; Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, EZ, Nijmegen, The Netherlands. j.naaijen@donders.ru.nl.
  • de Ruiter S; Karakter child and adolescent psychiatry university center, Nijmegen, The Netherlands.
  • Zwiers MP; Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, EZ, Nijmegen, The Netherlands.
  • Glennon JC; Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, EZ, Nijmegen, The Netherlands.
  • Durston S; NICHE lab, department of psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Lythgoe DJ; Department of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
  • Williams SC; Department of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
  • Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.
  • Brandeis D; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.
  • Franke B; Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland.
  • Buitelaar JK; Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
BMC Psychiatry ; 16(1): 361, 2016 10 26.
Article en En | MEDLINE | ID: mdl-27782808
ABSTRACT

BACKGROUND:

Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, which may be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in the aetiology of compulsivity-related disorders.

METHODS:

The COMPULS study is a multi-center study designed to investigate the relationship between the traits compulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disorders ADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total, 240 participants will take part in COMPULS across four different sites in Europe. Data collection will include diagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectral neuroimaging, and genome-wide genetic information.

DISCUSSION:

The COMPULS study will offer the unique opportunity to investigate several key aspects of compulsivity across a large cohort of ADHD, ASD and OCD patients.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Imagen por Resonancia Magnética / Cognición / Conducta Compulsiva / Predisposición Genética a la Enfermedad / Trastorno del Espectro Autista / Trastorno Obsesivo Compulsivo Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: BMC Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Imagen por Resonancia Magnética / Cognición / Conducta Compulsiva / Predisposición Genética a la Enfermedad / Trastorno del Espectro Autista / Trastorno Obsesivo Compulsivo Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: BMC Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos