[The expression of p27Kip1 and ß-catenin in multiple endocrine neoplasia type 1-related parathyroid tumors].
Zhonghua Nei Ke Za Zhi
; 55(11): 859-862, 2016 Nov 01.
Article
en Zh
| MEDLINE
| ID: mdl-27801341
ABSTRACT
Objective:
To explore tissue expression of cyclin-dependent kinase inhibitor p27Kip1 and ß-catenin in multiple endocrine neoplasia type1 (MEN1)-related parathyroid tumors (MHPT).Methods:
Immunohistochemistry was performed to analyze the expression of p27Kip1 and ß-catenin in parathyroid glands from 31 subjects with MHPT collected at Peking Union Medical College Hospital from 2002 to 2013. Five normal parathyroid glands were used as control.Results:
In MHPT subjects, nuclear expression of p27Kip1 was absent in 4 (12.9%), weak in 10 (32.3%) and moderated staining in 17 parathyroid specimens (54.8%), respectively. While, in normal subjects, the nuclear expression of p27Kip1 was observed in all subjects and was stronger than that from MHPT subjects (P=0.001). As to the expression of ß-catenin, normal parathyroid showed a distinct to moderate membrane staining, a moderate to weak cytoplasmic staining and negative nuclear staining. Similarly, MHPT exhibited a marked to moderate membrane (P=0.087), a moderated to weak cytoplasmic (P=0.357), and negative nuclear ß-catenin staining.Conclusions:
The expression of p27Kip1 is reduced or absent in MHPT tissue, and no nuclear expression of ß-catenin is observed in the tumors, which suggesting p27Kip1, but not ß-catenin nuclear accumulation, play a role in the development of the tumors.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de las Paratiroides
/
Neoplasia Endocrina Múltiple Tipo 1
/
Beta Catenina
/
Inhibidor p27 de las Quinasas Dependientes de la Ciclina
Límite:
Humans
Idioma:
Zh
Revista:
Zhonghua Nei Ke Za Zhi
Año:
2016
Tipo del documento:
Article
País de afiliación:
China