Test-retest reproducibility of extrastriatal binding with 123I-FP-CIT SPECT in healthy male subjects.
Psychiatry Res Neuroimaging
; 258: 10-15, 2016 Dec 30.
Article
en En
| MEDLINE
| ID: mdl-27814458
ABSTRACT
123I-labeled 2ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it can also quantify extrastriatal serotonin transporter (SERT) expressions. While FP-CIT uptake in extrastriatal regions has been quantified, no information exists on the reproducibility of the 123I-FP-CIT specific uptake ratio (SUR) in extrastriatal regions. We investigated test-retest reproducibility of 123I-FP-CIT binding in the striatum, the midbrain, and cortical regions in eight healthy male subjects. All subjects underwent two 123I-FP-CIT SPECT scans, and SUR was calculated using the cerebellum as the reference. We found good test-retest reproducibility of 123I-FP-CIT SUR in the midbrain, and in the lateral frontal/temporal cortex and combined cortical regions. The overall variability and intraclass correlation of SUR were, respectively, 4.9-7.8% and 0.90-0.96 in striatal regions, 8.6% and 0.79 in the midbrain, and 3.6-9.1% and 0.84-0.95 in the lateral frontal/temporal cortex and combined cortical regions. Our results provide evidence that 123I-FP-CIT SPECT is a valid technique for analyzing striatal DAT, as well as extrastriatal SERT in areas such as the SERT-enriched midbrain. In addition, our data suggest that 123I-FP-CIT could be used for analyzing SERT in regions with relatively low SERT expression (e.g., temporal or frontal cortices).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mesencéfalo
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Tomografía Computarizada de Emisión de Fotón Único
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Cerebelo
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Cuerpo Estriado
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Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
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Proteínas de Transporte de Serotonina en la Membrana Plasmática
Límite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Psychiatry Res Neuroimaging
Año:
2016
Tipo del documento:
Article
País de afiliación:
Japón