Randomized clinical trial of preoperative skin antisepsis with chlorhexidine gluconate or povidone-iodine.
Br J Surg
; 104(2): e145-e150, 2017 Jan.
Article
en En
| MEDLINE
| ID: mdl-27879993
ABSTRACT
BACKGROUND:
Skin antiseptic agents are used to prevent surgical-site infection (SSI); few trials have reported the superiority of any specific agent in clean-contaminated abdominal surgery. This RCT was designed to compare the effectiveness of chlorhexidine gluconate and povidone-iodine.METHODS:
Consecutive patients who underwent clean-contaminated upper gastrointestinal or hepatobiliary-pancreatic open surgery between 2011 and 2014 were assigned randomly to either chlorhexidine gluconate or povidone-iodine. The primary endpoint was the occurrence of SSI within 30 days of surgery. Secondary endpoints included causative organisms and risk factors for SSI.RESULTS:
A total of 534 patients were randomized; 31 (5·8 per cent) developed an SSI. There was no difference in the overall SSI rate in the chlorhexidine gluconate and povidone-iodine groups 15 of 267 (5·6 per cent) and 16 of 267 (6·0 per cent) respectively (P = 0·853). The most common causative organism was Enterococcus faecalis. In subgroup analysis, biliary-pancreatic surgery had a higher SSI rate (26 of 127, 20·5 per cent) than upper gastrointestinal (2 of 204, 1·0 per cent) and hepatic (3 of 203, 1·5 per cent) resection. Both age (60 years and over) and type of incision were associated with the risk of SSI.CONCLUSION:
No difference was detected between chlorhexidine gluconate and povidone-iodine antiseptics for prevention of SSI. Registration number NCT01495117 (http//www.clinicaltrials.gov).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Povidona Yodada
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Infección de la Herida Quirúrgica
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Cuidados Preoperatorios
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Clorhexidina
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Cuidados de la Piel
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Antiinfecciosos Locales
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
/
Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Br J Surg
Año:
2017
Tipo del documento:
Article
País de afiliación:
Corea del Sur