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Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice.
Wang, Weicang; Yang, Jun; Yang, Haixia; Sanidad, Katherine Z; Hammock, Bruce D; Kim, Daeyoung; Zhang, Guodong.
Afiliación
  • Wang W; Department of Food Science, University of Massachusetts, Amherst, MA, 01003, USA.
  • Yang J; Department of Entomology and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
  • Yang H; Department of Food Science, University of Massachusetts, Amherst, MA, 01003, USA.
  • Sanidad KZ; Department of Food Science, University of Massachusetts, Amherst, MA, 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, 01003, USA.
  • Hammock BD; Department of Entomology and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
  • Kim D; Department of Mathematics and Statistics, University of Massachusetts, Amherst, MA, 01003, USA.
  • Zhang G; Department of Food Science, University of Massachusetts, Amherst, MA, 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, 01003, USA. Electronic address: guodongzhang@umass.edu.
Article en En | MEDLINE | ID: mdl-27913146
ABSTRACT
Obesity is a serious health problem in the US and is associated with increased risks of various human diseases. To date, the mechanisms by which obesity increases the risks of a wide range of human diseases are not well understood. Here we used a LC-MS/MS-based lipidomics, which can analyze >100 bioactive lipid mediators produced by cyclooxygenase, lipoxygenase, and cytochrome P450 enzymes, to analyze plasma profiles of lipid mediators in high-fat diet induced obesity in C57BL/6 mice. Our results show that the plasma concentrations of epoxyoctadecenoic acids (EpOMEs, also termed as leukotoxins) are significantly increased in plasma of high-fat diet-fed mice, in addition, EpOMEs are among the most abundant lipid mediators detected in mouse plasma. Since substantial studies have shown that EpOMEs and their metabolites have a large array of detrimental effects on health, enhanced levels of EpOMEs could contribute to the pathology of obesity.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Eicosanoides / Dieta Alta en Grasa Límite: Animals Idioma: En Revista: Prostaglandins Other Lipid Mediat Asunto de la revista: ENDOCRINOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Eicosanoides / Dieta Alta en Grasa Límite: Animals Idioma: En Revista: Prostaglandins Other Lipid Mediat Asunto de la revista: ENDOCRINOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos