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The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology.
Armakolas, Nikolaos; Armakolas, Athanasios; Antonopoulos, Athanasios; Dimakakos, Andreas; Stathaki, Martha; Koutsilieris, Michael.
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  • Armakolas N; Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece; Third orthopaedic clinic, KAT General Hospital, Kifisia, Attiki, Greece. Electronic address: narmakolas@gmail.com.
  • Armakolas A; Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: aarmakol@med.uoa.gr.
  • Antonopoulos A; Third orthopaedic clinic, KAT General Hospital, Kifisia, Attiki, Greece. Electronic address: thanosarmakolas@yahoo.com.
  • Dimakakos A; Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: dhmakak@med.uoa.gr.
  • Stathaki M; Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: stathakimg@yahoo.gr.
  • Koutsilieris M; Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: mkoutsil@med.uoa.gr.
Crit Rev Oncol Hematol ; 108: 137-145, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27931832
Growth hormone (GH) regulated mainly liver-produced insulin-like growth factor 1 (IGF-1) is a key molecule in embryonic & post embryonic development that is also involved in cancer biology. Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Óseas / Factor I del Crecimiento Similar a la Insulina / Osteosarcoma Límite: Animals / Humans Idioma: En Revista: Crit Rev Oncol Hematol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2016 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Óseas / Factor I del Crecimiento Similar a la Insulina / Osteosarcoma Límite: Animals / Humans Idioma: En Revista: Crit Rev Oncol Hematol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2016 Tipo del documento: Article