Soluble HLA-G concentrations in obese women during pregnancy and in cord blood.
J Reprod Immunol
; 119: 31-37, 2017 02.
Article
en En
| MEDLINE
| ID: mdl-27984763
ABSTRACT
CONTEXT Little is known about soluble HLA-G (sHLA-G) concentrations in obese pregnant women with uncomplicated pregnancies. OBJECTIVE:
To investigate the role of sHLA-G in obese pregnancies.DESIGN:
Case-control study, from 2013 to 2015.SETTING:
A tertiary care centre. PATIENTS 168 healthy normal weight women and 59 overweight/obese women; to avoid the effect of preeclampsia on sHLA-G concentrations, cases were further divided in two groups 42 with normotensive pregnancy and 17 who developed preeclampsia.INTERVENTIONS:
all the women enrolled received standard antenatal care and plasma sample collections were performed. MAIN OUTCOMEMEASURES:
sHLA-G concentrations during pregnancy, before delivery and in cord blood.RESULTS:
Maternal sHLA-G concentrations in overweight/obese with normotensive pregnancies increased by 14.7% (IQR=-26.4 to +89.6) in the 2nd trimester and by 19.6% (IQR=-33 to +104) before delivery and were significantly higher than in controls (p=0.024). Median cord blood sHLA-G concentrations were 53.5ng/ml (IQR=36-62.7) in the overweight/obese women with uncomplicated pregnancies (p<0.001 compared to controls) and 19.7ng/ml (IQR=7.5-36.3) in controls. Maternal concentrations of sHLA-G in the two trimesters and before delivery were significantly lower among subjects who developed preeclampsia than in controls (p<0.001) or in obese subjects with normotensive pregnancies (p<0.001).CONCLUSIONS:
sHLA-G concentratons are higher in normotensive overweight/obese women and their babies while lower in preeclamptic overweight/obese women and their cords. Obesity influences maternal and fetal sHLA-G concentrations during pregnancy, to optimize the reproductive success, while preeclampsia impairs the mother-offspring antinflammatory response.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Sangre Fetal
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Antígenos HLA-G
/
Obesidad
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
J Reprod Immunol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia