C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism.

Liu, Liang; Chen, Peng; Wang, Min; Li, Xueyan; Wang, Jiuyu; Yin, Maolu; Wang, Yanli

Liu, Liang; Chen, Peng; Wang, Min; Li, Xueyan; Wang, Jiuyu; Yin, Maolu; Wang, Yanli.

Afiliación

Liu L; Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Chen P; Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang M; Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Li X; Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang J; Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Yin M; Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang Y; Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Collaborative Innovation Center of Genetics and Development, Shanghai 200438,

Mol Cell ; 65(2): 310-322, 2017 Jan 19.

Article en En | MEDLINE | ID: mdl-27989439

Asunto(s)

Alicyclobacillus/enzimología; Proteínas Bacterianas/metabolismo; Proteínas Asociadas a CRISPR/metabolismo; Sistemas CRISPR-Cas; Roturas del ADN de Doble Cadena; ADN Bacteriano/metabolismo; Endodesoxirribonucleasas/metabolismo; Ácidos Nucleicos Heterodúplex/metabolismo; ARN Bacteriano/metabolismo; ARN Guía de Kinetoplastida/metabolismo; Alicyclobacillus/genética; Proteínas Bacterianas/química; Proteínas Bacterianas/genética; Proteínas Asociadas a CRISPR/química; Proteínas Asociadas a CRISPR/genética; Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas; ADN Bacteriano/química; ADN Bacteriano/genética; Endodesoxirribonucleasas/química; Endodesoxirribonucleasas/genética; Modelos Moleculares; Conformación de Ácido Nucleico; Ácidos Nucleicos Heterodúplex/química; Ácidos Nucleicos Heterodúplex/genética; Unión Proteica; Dominios y Motivos de Interacción de Proteínas; ARN Bacteriano/química; ARN Bacteriano/genética; ARN Guía de Kinetoplastida/química; ARN Guía de Kinetoplastida/genética; Relación Estructura-Actividad

Palabras clave

C2c1; CRISPR-Cas system; DNA endonuclease; crystal structure; genome-editing

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / ADN Bacteriano / ARN Bacteriano / ARN Guía de Kinetoplastida / Endodesoxirribonucleasas / Roturas del ADN de Doble Cadena / Alicyclobacillus / Proteínas Asociadas a CRISPR / Sistemas CRISPR-Cas / Ácidos Nucleicos Heterodúplex Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google