Cerium oxide nanoparticles: the regenerative redox machine in bioenergetic imbalance.
Nanomedicine (Lond)
; 12(4): 403-416, 2017 02.
Article
en En
| MEDLINE
| ID: mdl-28000542
ABSTRACT
AIM:
Owing to their catalytic properties as reactive oxygen species scavengers, cerium oxide nanoparticles (nanoceria) have become an extremely promising candidate for medical applications, especially in the treatment of diseases where oxidative stress has been proposed as one of the main pathogenesis factors. MATERIALS &METHODS:
In this work, nanoceria antioxidant power has been tested in primary cultured skin fibroblasts, derived from healthy individuals, by evaluating the mitochondrial function both in basal condition and after an oxidative insult. RESULTS &CONCLUSION:
Combined with a clear lack of toxicity, antioxidant activity makes nanoceria promising in a wide range of clinical applications sharing the common signature of a global bioenergetic dysfunction.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
Cerio
/
Nanopartículas
/
Fibroblastos
/
Antioxidantes
Límite:
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia