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Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity.
Wu, Hai-Yan; Sheng, Yu; Kan, Xue-Qin; Mou, Lin-Yun; Hu, Qiu-Feng; Li, Gan-Peng.
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  • Wu HY; a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
  • Sheng Y; a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
  • Kan XQ; a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
  • Mou LY; a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
  • Hu QF; a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
  • Li GP; a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
J Asian Nat Prod Res ; 19(8): 774-779, 2017 Aug.
Article en En | MEDLINE | ID: mdl-28030961
Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Swertia / Xantonas / Inhibidores de 5-alfa-Reductasa Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Swertia / Xantonas / Inhibidores de 5-alfa-Reductasa Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: China