O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1.

Guo, Huabei; Zhang, Bing; Nairn, Alison V; Nagy, Tamas; Moremen, Kelley W; Buckhaults, Phillip; Pierce, Michael

O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1.

Guo, Huabei; Zhang, Bing; Nairn, Alison V; Nagy, Tamas; Moremen, Kelley W; Buckhaults, Phillip; Pierce, Michael.

Afiliación

Guo H; From the Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, and.
Zhang B; the Boston Children's Hospital, Harvard University, Boston, Massachusetts 02115, and.
Nairn AV; From the Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, and.
Nagy T; Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602.
Moremen KW; From the Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, and.
Buckhaults P; the South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208.
Pierce M; From the Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, and hawkeye@uga.edu.

J Biol Chem ; 292(10): 4123-4137, 2017 03 10.

Article en En | MEDLINE | ID: mdl-28096468

Asunto(s)

Acetilglucosamina/metabolismo; Transformación Celular Neoplásica/patología; Neoplasias del Colon/patología; Epigénesis Genética/genética; Regulación Neoplásica de la Expresión Génica; Células Madre Neoplásicas/patología; Proteínas Proto-Oncogénicas/genética; Transactivadores/genética; Animales; Apoptosis; Western Blotting; Transformación Celular Neoplásica/genética; Transformación Celular Neoplásica/metabolismo; Neoplasias del Colon/genética; Neoplasias del Colon/metabolismo; Humanos; Ratones; Ratones Endogámicos NOD; Ratones SCID; Células Madre Neoplásicas/metabolismo; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

O-linked N-acetylglucosamine (O-GlcNAc); colon cancer; epigenetics; gene knockout; glycosylation; glycosyltransferase; stem cells

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acetilglucosamina / Células Madre Neoplásicas / Regulación Neoplásica de la Expresión Génica / Transactivadores / Transformación Celular Neoplásica / Proteínas Proto-Oncogénicas / Neoplasias del Colon / Epigénesis Genética Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article

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