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Deheiculatins A-L, 20-oxygenated cembranoids from Macaranga deheiculata.
Qi, Wei-Yan; Shen, Yu; Wu, Yan; Leng, Ying; Gao, Kun; Yue, Jian-Min.
Afiliación
  • Qi WY; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Shen Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
  • Wu Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
  • Leng Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
  • Gao K; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: npchem@lzu.edu.cn.
  • Yue JM; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republ
Phytochemistry ; 136: 101-107, 2017 Apr.
Article en En | MEDLINE | ID: mdl-28117097
ABSTRACT
Twelve cembranoids, deheiculatins A-L, were isolated from the leaves and twigs of Macaranga deheiculata. Their structures were elucidated on the basis of spectroscopic data. Five of these compounds displayed moderate inhibitory activity against human and/or mouse 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). 20-Oxygenated cembranes are rare.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Euphorbiaceae / 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1 / Diterpenos Límite: Animals / Humans Idioma: En Revista: Phytochemistry Año: 2017 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Euphorbiaceae / 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1 / Diterpenos Límite: Animals / Humans Idioma: En Revista: Phytochemistry Año: 2017 Tipo del documento: Article