A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH<sub>2</sub> versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH<sub>2</sub>: A Bivalent Advantage.

Lensing, Cody J; Adank, Danielle N; Wilber, Stacey L; Freeman, Katie T; Schnell, Sathya M; Speth, Robert C; Zarth, Adam T; Haskell-Luevano, Carrie

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH₂ versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH₂: A Bivalent Advantage.

Lensing, Cody J; Adank, Danielle N; Wilber, Stacey L; Freeman, Katie T; Schnell, Sathya M; Speth, Robert C; Zarth, Adam T; Haskell-Luevano, Carrie.

Afiliación

Lensing CJ; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Adank DN; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Wilber SL; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Freeman KT; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Schnell SM; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Speth RC; College of Pharmacy, Nova Southeastern University , Fort Lauderdale, Florida 33328-2018, United States.
Zarth AT; Department of Pharmacology and Physiology, Georgetown University , Washington, D.C. 20057, United States.
Haskell-Luevano C; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.

ACS Chem Neurosci ; 8(6): 1262-1278, 2017 06 21.

Article en En | MEDLINE | ID: mdl-28128928

Asunto(s)

Metabolismo Energético/efectos de los fármacos; Oligopéptidos/química; Oligopéptidos/farmacología; Receptores de Melanocortina/agonistas; Animales; Ingestión de Alimentos/efectos de los fármacos; Células HEK293; Humanos; Ligandos; Ratones; Oligopéptidos/síntesis química; Receptores de Melanocortina/efectos de los fármacos

Palabras clave

BRET; MC3R-MC4R heterodimer; Melanocortin homodimer; interleukin-6; magnetic resonance imagining; melanotropin; metabolic serum stability; metabolic syndrome; obesity

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Receptores de Melanocortina / Metabolismo Energético Límite: Animals / Humans Idioma: En Revista: ACS Chem Neurosci Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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