Effects on breathing of agonists to µ-opioid or GABAA receptors dialyzed into the ventral respiratory column of awake and sleeping goats.
Respir Physiol Neurobiol
; 239: 10-25, 2017 05.
Article
en En
| MEDLINE
| ID: mdl-28137700
ABSTRACT
Pulmonary ventilation (VÌI) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC). Concomitant changes in excitatory neuromodulators in the effluent mock cerebral spinal fluid (mCSF) suggest neuromodulatory compensation. Herein, we studied neuromodulatory compensation during dialysis of agonists to inhibitory G protein-coupled or ionotropic receptors into the VRC. Microtubules were implanted into the VRC of goats for dialysis of mCSF mixed with agonists to either µ-opioid (DAMGO) or GABAA (muscimol) receptors. We found (1) VÌI decreased during unilateral but increased during bilateral dialysis of DAMGO, (2) dialyses of DAMGO destabilized breathing, (3) unilateral dialysis of muscimol increased VÌI, and (4) dialysis of DAMGO decreased GABA in the effluent mCSF. We conclude (1) neuromodulatory compensation can occur during altered inhibitory neuromodulator receptor activity, and (2) the mechanism of compensation differs between G protein-coupled excitatory and inhibitory receptors and between G protein-coupled and inotropic inhibitory receptors.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Respiración
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Centro Respiratorio
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Encefalina Ala(2)-MeFe(4)-Gli(5)
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Agonistas de Receptores de GABA-A
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Analgésicos Opioides
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Muscimol
Límite:
Animals
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos