Low-Dose Aspirin Acetylates Cyclooxygenase-1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer.

Patrignani, P; Sacco, A; Sostres, C; Bruno, A; Dovizio, M; Piazuelo, E; Di Francesco, L; Contursi, A; Zucchelli, M; Schiavone, S; Tacconelli, S; Patrono, C; Lanas, A

Patrignani, P; Sacco, A; Sostres, C; Bruno, A; Dovizio, M; Piazuelo, E; Di Francesco, L; Contursi, A; Zucchelli, M; Schiavone, S; Tacconelli, S; Patrono, C; Lanas, A.

Afiliación

Patrignani P; Section of Cardiovascular and Pharmacological Sciences, Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University, Chieti, Italy.
Sacco A; CeSI-MeT (Centro Scienze dell' Invecchiamento e Medicina Traslazionale), "G. d'Annunzio" University, Chieti, Italy.
Sostres C; Section of Cardiovascular and Pharmacological Sciences, Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University, Chieti, Italy.
Bruno A; CeSI-MeT (Centro Scienze dell' Invecchiamento e Medicina Traslazionale), "G. d'Annunzio" University, Chieti, Italy.
Dovizio M; University Hospital LB, Aragon Health Research Institute (IISAragon), CIBERehd, University of Zaragoza, Zaragoza, Spain.
Piazuelo E; Section of Cardiovascular and Pharmacological Sciences, Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University, Chieti, Italy.
Di Francesco L; CeSI-MeT (Centro Scienze dell' Invecchiamento e Medicina Traslazionale), "G. d'Annunzio" University, Chieti, Italy.
Contursi A; Section of Cardiovascular and Pharmacological Sciences, Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University, Chieti, Italy.
Zucchelli M; CeSI-MeT (Centro Scienze dell' Invecchiamento e Medicina Traslazionale), "G. d'Annunzio" University, Chieti, Italy.
Schiavone S; University Hospital LB, Aragon Health Research Institute (IISAragon), CIBERehd, University of Zaragoza, Zaragoza, Spain.
Tacconelli S; Section of Cardiovascular and Pharmacological Sciences, Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University, Chieti, Italy.
Patrono C; CeSI-MeT (Centro Scienze dell' Invecchiamento e Medicina Traslazionale), "G. d'Annunzio" University, Chieti, Italy.
Lanas A; Section of Cardiovascular and Pharmacological Sciences, Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University, Chieti, Italy.

Clin Pharmacol Ther ; 102(1): 52-61, 2017 07.

Article en En | MEDLINE | ID: mdl-28139830

Asunto(s)

Aspirina; Plaquetas; Neoplasias Colorrectales; Ciclooxigenasa 1/metabolismo; Dinoprostona/biosíntesis; Mucosa Intestinal; Proteínas Quinasas S6 Ribosómicas/metabolismo; Acetilación/efectos de los fármacos; Aspirina/administración & dosificación; Aspirina/farmacocinética; Biopsia/métodos; Plaquetas/efectos de los fármacos; Plaquetas/enzimología; Carcinogénesis/efectos de los fármacos; Carcinogénesis/metabolismo; Neoplasias Colorrectales/sangre; Neoplasias Colorrectales/enzimología; Neoplasias Colorrectales/patología; Neoplasias Colorrectales/prevención & control; Inhibidores de la Ciclooxigenasa/administración & dosificación; Inhibidores de la Ciclooxigenasa/farmacocinética; Relación Dosis-Respuesta a Droga; Femenino; Humanos; Mucosa Intestinal/efectos de los fármacos; Mucosa Intestinal/enzimología; Masculino; Persona de Mediana Edad; Fosforilación/efectos de los fármacos; Resultado del Tratamiento

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plaquetas / Neoplasias Colorrectales / Dinoprostona / Aspirina / Proteínas Quinasas S6 Ribosómicas / Ciclooxigenasa 1 / Mucosa Intestinal Tipo de estudio: Clinical_trials Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Año: 2017 Tipo del documento: Article País de afiliación: Italia

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