Usefulness of bronchoalveolar lavage and flow cytometry in patients with hematological malignancies and respiratory failure. / Utilidad del lavado broncoalveolar y la citometría de flujo en pacientes con hemopatías malignas e insuficiencia respiratoria.
Med Clin (Barc)
; 148(7): 297-302, 2017 Apr 07.
Article
en En, Es
| MEDLINE
| ID: mdl-28143650
ABSTRACT
BACKGROUND AND OBJECTIVES:
Strategies to improve the efficiency of bronchoalveolar lavage (BAL) are needed. We conducted a study to establish the diagnostic value of BAL in patients with hematological malignancies and pulmonary infiltrates. PATIENTS ANDMETHODS:
The correlation of cytologic and flow cytometric study of BAL with the microbiological findings and the clinical evolution was determined.RESULTS:
Seventy BAL were performed and flow cytometric study was analyzed in 23 of them. Fifty-three patients did not present any adverse event attributable to BAL. Anti-infectious therapy was modified in 64 (91%) patients. T lymphocyte count >0.3×109/l in peripheral blood was associated with longer OS at 3 years (53 vs. 22%, p=.009). Higher CD4 (>20/µL) and CD8 (>35/µL) lymphocyte counts in the BAL were associated with a longer OS at 3 years 82 vs. 21% (p=.030) and 80 vs. 23% (p=.059).CONCLUSIONS:
Our study confirms the clinical value of BAL for treatment decision making in patients with hematological malignancies and acute respiratory failure.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Insuficiencia Respiratoria
/
Infiltración Leucémica
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Lavado Broncoalveolar
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Neoplasias Hematológicas
/
Citometría de Flujo
/
Pulmón
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
/
Es
Revista:
Med Clin (Barc)
Año:
2017
Tipo del documento:
Article