Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines.

Beesu, Mallesh; Salyer, Alex C D; Brush, Michael J H; Trautman, Kathryn L; Hill, Justin K; David, Sunil A

Beesu, Mallesh; Salyer, Alex C D; Brush, Michael J H; Trautman, Kathryn L; Hill, Justin K; David, Sunil A.

Afiliación

Beesu M; Department of Medicinal Chemistry, University of Minnesota , Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Salyer AC; Department of Medicinal Chemistry, University of Minnesota , Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Brush MJ; Department of Medicinal Chemistry, University of Minnesota , Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Trautman KL; Department of Medicinal Chemistry, University of Minnesota , Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Hill JK; Department of Medicinal Chemistry, University of Minnesota , Sixth Street SE, Minneapolis, Minnesota 55455, United States.
David SA; Department of Medicinal Chemistry, University of Minnesota , Sixth Street SE, Minneapolis, Minnesota 55455, United States.

J Med Chem ; 60(5): 2084-2098, 2017 03 09.

Article en En | MEDLINE | ID: mdl-28146629

Asunto(s)

Diaminas/farmacología; Pirimidinas/farmacología; Receptor Toll-Like 7/agonistas; Receptor Toll-Like 8/agonistas; Diaminas/química; Humanos; Pirimidinas/química

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Diaminas / Receptor Toll-Like 7 / Receptor Toll-Like 8 Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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