Oxidized and Original article degraded mitochondrial polynucleotides (DeMPs), especially RNA, are potent immunogenic regulators in primary mouse macrophages.

Saxena, Abhinav R; Gao, Linda Y; Srivatsa, Shachi; Bobersky, Elizabeth Z; Periasamy, Sivakumar; Hunt, Danielle T; Altman, Kyle E; Crawford, Dana R

Saxena, Abhinav R; Gao, Linda Y; Srivatsa, Shachi; Bobersky, Elizabeth Z; Periasamy, Sivakumar; Hunt, Danielle T; Altman, Kyle E; Crawford, Dana R.

Afiliación

Saxena AR; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA; St. George's University School of Medicine, Grenada, West Indies.
Gao LY; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Srivatsa S; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Bobersky EZ; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Periasamy S; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Hunt DT; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Altman KE; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Crawford DR; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA. Electronic address: crawfod@mail.amc.edu.

Free Radic Biol Med ; 104: 371-379, 2017 03.

Article en En | MEDLINE | ID: mdl-28179110

Asunto(s)

Macrófagos/metabolismo; Mitocondrias/efectos de los fármacos; Estrés Oxidativo/efectos de los fármacos; ARN/genética; Animales; Citocinas/biosíntesis; ADN Mitocondrial/efectos de los fármacos; ADN Mitocondrial/genética; ADN Mitocondrial/metabolismo; Peróxido de Hidrógeno/toxicidad; Macrófagos/efectos de los fármacos; Macrófagos/patología; Ratones; Mitocondrias/metabolismo; Mitocondrias/patología; Mitofagia/efectos de los fármacos; Mitofagia/genética; Oxidación-Reducción; Estrés Oxidativo/genética; ARN/metabolismo; Estabilidad del ARN/efectos de los fármacos; Estabilidad del ARN/genética; ARN Mitocondrial

Palabras clave

DAMPs; DeMPs; Degraded mitochondrial polynucleotides; Hydrogen peroxide; Macrophages; Mitochondria; Oxidative stress; Proinflammatory cytokine

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ARN / Estrés Oxidativo / Macrófagos / Mitocondrias Límite: Animals Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2017 Tipo del documento: Article

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