The impact of different mutations at Arg54 on structure, chaperone-like activity and oligomerization state of human &#945;A-crystallin: The pathomechanism underlying congenital cataract-causing mutations R54L, R54P and R54C.

Khoshaman, Kazem; Yousefi, Reza; Tamaddon, Ali Mohammad; Abolmaali, Samira Sadat; Oryan, Ahmad; Moosavi-Movahedi, Ali Akbar; Kurganov, Boris I

The impact of different mutations at Arg54 on structure, chaperone-like activity and oligomerization state of human αA-crystallin: The pathomechanism underlying congenital cataract-causing mutations R54L, R54P and R54C.

Khoshaman, Kazem; Yousefi, Reza; Tamaddon, Ali Mohammad; Abolmaali, Samira Sadat; Oryan, Ahmad; Moosavi-Movahedi, Ali Akbar; Kurganov, Boris I.

Afiliación

Khoshaman K; Protein Chemistry Laboratory (PCL), Department of Biology, Shiraz University, Shiraz, Iran.
Yousefi R; Protein Chemistry Laboratory (PCL), Department of Biology, Shiraz University, Shiraz, Iran. Electronic address: ryousefi@shirazu.ac.ir.
Tamaddon AM; Center for Nanotechnology in Drug Delivery and School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Abolmaali SS; Center for Nanotechnology in Drug Delivery and School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Oryan A; Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Moosavi-Movahedi AA; Institute of Biochemistry and Biophysics (IBB), The University of Tehran, Tehran, Iran.
Kurganov BI; Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Ave. 33, bld. 2, Moscow 119071, Russia.

Biochim Biophys Acta Proteins Proteom ; 1865(5): 604-618, 2017 May.

Article en En | MEDLINE | ID: mdl-28179137

Asunto(s)

Arginina/química; Catarata/genética; Cristalinas/química; Proteínas Mutantes/química; Arginina/genética; Catarata/metabolismo; Catarata/patología; Dicroismo Circular; Cristalinas/genética; Cristalinas/metabolismo; Humanos; Cristalino/química; Cristalino/metabolismo; Cristalino/patología; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Mutación Missense; Unión Proteica; Pliegue de Proteína; Estabilidad Proteica; Estructura Cuaternaria de Proteína; Relación Estructura-Actividad

Palabras clave

Cataract; Chaperone; Crystallin; Protein aggregation; Protein stability; αA-crystallin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arginina / Catarata / Cristalinas / Proteínas Mutantes Límite: Humans Idioma: En Revista: Biochim Biophys Acta Proteins Proteom Año: 2017 Tipo del documento: Article País de afiliación: Irán

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