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Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.
Pomowski, Anja; Usón, Isabel; Nowakowska, Zuzanna; Veillard, Florian; Sztukowska, Maryta N; Guevara, Tibisay; Goulas, Theodoros; Mizgalska, Danuta; Nowak, Magdalena; Potempa, Barbara; Huntington, James A; Potempa, Jan; Gomis-Rüth, F Xavier.
Afiliación
  • Pomowski A; From the Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom.
  • Usón I; the Proteolysis Lab and Crystallographic Methods Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas, 08028 Barcelona, Catalonia, Spain.
  • Nowakowska Z; the Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Catalonia, Spain.
  • Veillard F; the Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland, and.
  • Sztukowska MN; the Department of Oral Immunology and Infectious Disease, University of Louisville School of Dentistry, Louisville, Kentucky 40202.
  • Guevara T; the Department of Oral Immunology and Infectious Disease, University of Louisville School of Dentistry, Louisville, Kentucky 40202.
  • Goulas T; the Proteolysis Lab and Crystallographic Methods Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas, 08028 Barcelona, Catalonia, Spain.
  • Mizgalska D; the Proteolysis Lab and Crystallographic Methods Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas, 08028 Barcelona, Catalonia, Spain.
  • Nowak M; the Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland, and.
  • Potempa B; the Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland, and.
  • Huntington JA; the Department of Oral Immunology and Infectious Disease, University of Louisville School of Dentistry, Louisville, Kentucky 40202.
  • Potempa J; From the Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom.
  • Gomis-Rüth FX; the Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland, and jan.potempa@louisville.edu.
J Biol Chem ; 292(14): 5724-5735, 2017 04 07.
Article en En | MEDLINE | ID: mdl-28196869
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cisteína Endopeptidasas / Porphyromonas gingivalis / Adhesinas Bacterianas / Factores de Virulencia / Precursores Enzimáticos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cisteína Endopeptidasas / Porphyromonas gingivalis / Adhesinas Bacterianas / Factores de Virulencia / Precursores Enzimáticos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido