HemoPred: a web server for predicting the hemolytic activity of peptides.
Future Med Chem
; 9(3): 275-291, 2017 Mar.
Article
en En
| MEDLINE
| ID: mdl-28211294
ABSTRACT
AIM:
Toxicity arising from hemolytic activity of peptides hinders its further progress as drug candidates. MATERIALS &METHODS:
This study describes a sequence-based predictor based on a random forest classifier using amino acid composition, dipeptide composition and physicochemical descriptors (named HemoPred).RESULTS:
This approach could outperform previously reported method and typical classification methods (e.g., support vector machine and decision tree) verified by fivefold cross-validation and external validation with accuracy and Matthews correlation coefficient in excess of 95% and 0.91, respectively. Results revealed the importance of hydrophobic and Cys residues on α-helix and ß-sheet, respectively, on the hemolytic activity.CONCLUSION:
A sequence-based predictor which is publicly available as the web service of HemoPred, is proposed to predict and analyze the hemolytic activity of peptides.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Hemolíticos
/
Aprendizaje Automático
/
Hemólisis
Tipo de estudio:
Evaluation_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2017
Tipo del documento:
Article
País de afiliación:
Tailandia