The Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Late-Onset Alzheimer's disease: Further Evidence in an Italian Multicenter Study.
J Alzheimers Dis
; 56(4): 1451-1457, 2017.
Article
en En
| MEDLINE
| ID: mdl-28211809
ABSTRACT
BACKGROUND:
A functional polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, namely C677T (rs1801133), results in increased Hcy levels and has been associated with risk of late-onset Alzheimer's disease (LOAD). Many investigators reported association between rs1801133 and LOAD risk in Asian populations and in carriers of the apolipoprotein E (APOE) É4 allele, but recent meta-analyses suggest a contribution also in other populations, including Caucasians and/or northern Africans.OBJECTIVE:
To further address this issue, we performed a relatively large case-control study, including 581 LOAD patients and 468 matched controls of Italian origin. APOE data were available for a subgroup of almost 600 subjects.METHODS:
Genotyping for rs1801133 was performed with PCR-RFLP techniques.RESULTS:
In the total population, the MTHFR 677T allele (ORâ=â1.20; 95% CIâ=â1.01-1.43) and carriers of the MTHFR 677T allele (CT+TT versus CC ORâ=â1.34; 95% CIâ=â1.03-1.73) resulted in increased LOAD risk. Similarly, in APOEÉ4 carriers, we observed an increased frequency of MTHFR 677CT carriers (CT versus CC ORâ=â2.82; 95% CIâ=â1.25-6.32). Very interestingly, also in non-APOEÉ4 carriers, both MTHFR 677T allele (ORâ=â1.38; 95% CIâ=â1.03-1.85) and MTHFR 677TT genotype (ORâ=â2.08; 95% CIâ=â1.11-3.90) were associated with LOAD. All these associations survived after corrections for age, gender, and multiple testing.CONCLUSIONS:
The present results suggest that the MTHFR C677T polymorphism is likely a LOAD risk factor in our cohort, either in APOEÉ4 or in non-APOEÉ4 carriers.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Predisposición Genética a la Enfermedad
/
Metilenotetrahidrofolato Reductasa (NADPH2)
/
Enfermedad de Alzheimer
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia